Marshall was hoping to enter the Steel City and come away with its sixth win of the season and second on the road in the 2018-19 campaign.
But unfortunately, the Dukes of Duquesne got the win by a final of 93-82.
C.J. Burks paced the Herd with 26 points.
The loss moved Marshall to 5-3 on the year.
The Herd will next be in action on Saturday at home against the Rockets of Toledo.
Game time is 2:30 from the Cam Henderson Center and the showdown will air live on Stadium.